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What is Psilocybin?

Psilocybin is a naturally occurring psychedelic compound found in over 180 species of mushrooms, most commonly known as "magic mushrooms." Indigenous cultures have worked with these mushrooms in spiritual and healing contexts for thousands of years, and today psilocybin sits at the center of a growing body of scientific research into mental health and healing. Chemically, psilocybin belongs to the tryptamine family, the same class of compounds as DMT and serotonin. Once ingested, it's converted in the body to psilocin, which binds to serotonin receptors in the brain, primarily the 5-HT2A receptor. Effects typically begin within 20 to 60 minutes and last four to six hours, though the felt sense of time can shift considerably depending on dose and setting.

People often describe a mix of visual and auditory shifts, heightened emotion, and a loosening of the usual boundaries of self, sometimes referred to as ego dissolution. Many report deep introspection, a felt sense of unity with nature or something larger than themselves, and moments of real emotional insight. Lower doses tend to feel lighter and more creative, while higher doses can open into something far more expansive and, for many, genuinely mystical.

This renewed scientific interest isn't just anecdotal. Research out of institutions like Johns Hopkins and Imperial College London has shown that even one or two guided psilocybin sessions can produce meaningful, lasting shifts for people dealing with treatment-resistant depression, anxiety, PTSD, end-of-life distress, and addiction to substances like alcohol and tobacco.

Daytime Psilocybin Ceremony at Leaf and deVine

Join us for a transformative daytime psilocybin ceremony held in the sacred, supportive space of Leaf and deVine. Rooted in reverence for the sacrament and for the tradition of spiritual healing it comes from, this intimate journey is designed to help you reconnect with your inner wisdom, release emotional blocks, and cultivate clarity, peace, and purpose.

Guided by experienced, trauma-informed facilitators and held within a grounded, harm reduction-focused container, the day begins with intention-setting and grounding practices. From there, you'll move into the ceremonial experience with psilocybin-containing mushrooms, supported by music, breath, and the wisdom of the Earth. The ceremony closes with integration practices to help you process and begin to embody what surfaced during your journey.

 

This group meets twice for preparation on Sunday afternoons in the weeks leading up to ceremony. Meeting links are shared in the dedicated chat thread and posted to the Aya Denver "Events" tab. Attendance at both prep meetings is mandatory for anyone sitting in ceremony with us. Prep meetings are free as long as you attend at the scheduled time; make-up sessions are $50 each, in respect for our facilitators' time. Each participant also completes a mandatory individual intake, scheduled in the weeks prior to ceremony.

 

Participants must arrange a ride home and may not drive after ceremony. Everyone completes a screening covering medical history, medications, and psychological readiness, and a urinalysis is conducted before ceremony to screen for opiates, benzodiazepines, amphetamines, and cocaine. THC is not disqualifying, though abstaining from cannabis beforehand is recommended. Psilocybin isn't right for everyone. Contraindications include a history of psychosis, schizophrenia, or bipolar I disorder; certain seizure disorders; serious heart conditions; pregnancy or breastfeeding; and certain medications, including SNRIs, MAOIs, antipsychotics, mood stabilizers, and select stimulants.

We're always glad to talk through questions and help you figure out whether this ceremony is a safe, supportive fit for you.

For more information, call 720.993.9875 or 918.899.1351.


This ceremony is open to both newcomers and experienced journeyers, and is offered in the spirit of healing, connection, and spiritual exploration. 

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“Psilocybin allowed me to face my grief, not as a weight to carry, but as a teacher. I left that experience lighter, more whole.”

 ~Patient in a clinical study at NYU

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